Enzyme-inspired dry-powder polymeric catalyst for green and fast pharmaceutical manufacturing processes
نویسندگان
چکیده
Catalysis in pharma manufacturing processes is typically homogeneous, expensive and with hard catalyst recovery/regeneration. Herein an enzyme-inspired dry-powder molecularly imprinted polymeric (MIP) system was designed for fast, selective oxidation of a cholesterol derivative easy regeneration. The strategy involved the synthesis template-monomer (T:M) complex followed by crosslinked polymerization supercritical carbon dioxide (scCO2). A 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-MIP obtained after template cleavage from matrix, NH groups turns available TEMPO moieties within MIP. benzyl alcohol, 5?-cholestan-3?-ol cholic acid high yield capacity.
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ژورنال
عنوان ژورنال: Catalysis Communications
سال: 2022
ISSN: ['1566-7367', '1873-3905']
DOI: https://doi.org/10.1016/j.catcom.2022.106537